Krita is a replacement for Photoshop. You can load PSDs with layers, with high colors. Way better than GIMP.
https://krita.org/

WPS Office is a fantastic replacement for Microsoft Office. Even better than Libra Office, but Libra Office is improving fast. http://wps.com/linux/

QUICKEN:
Money Dance: http://moneydance.com/
Xero: https://www.xero.com/

AUTOCAD
Cademia: http://www.cademia.de/frontend…
Varicad: http://www.varicad.com/en/home…

SOUNDFORGE
Ocenaudio: http://www.ocenaudio.com.br/
Audio Sauna: http://www.audiosauna.com/Ardour: http://ardour.org/

CorelDraw
Bloom: http://www.thebloomapp.com/fea…
Inkscape: https://inkscape.org/en/
Blender: http://www.blender.org/

BluRay/DVD authoring
Light Works: http://www.lwks.com/
Davinci Resolve: https://www.blackmagicdesign.c…

Steam is on Linux

Unity is now on Linux.
http://blogs.unity3d.com/2015/…

Unreal Engine for Linux: https://www.unrealengine.com/b…

Visual Studio now works on Linux: https://code.visualstudio.com/…

.net was opened sourced, which is a huge boon for Mono.

We also have Docker containers being integrated into system such as Ubuntu with Snappy. I also suggest checking out Deepin Linux. I am waiting for 2015 version as there were a couple of bugs in their system they are working out.

Note: Flash is basically dead with Firefox and Chrome making the transition to remove it. That means video is switching to HTML5. I don’t know if you get the same screen tearing with HTML5, but it seems like a good thing.